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KMID : 1134819970260010144
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 1 p.144 ~ p.147
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Effects of Sesquiterpene Lactones Isolated from Chrysanthemum boreale M. against Sarcoma180 Implanted in ICR Mice
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Nam Sang-Hae
Choi Sang-Do
Choi Jine-Shang
Jang Dae-Sik
Choi Shang-Jine
Yang Min-Suk
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Abstract
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For the investigation of antitumor agents, two kinds of sesquiterpene lactones were isolated and purified from Chrysanthemum boreale M. and designated as Compound Ⅰ and Ⅱ. And then in vivo antitumor test of the sesquiterpene lactones was carried out against ICR mice. In vivo test against Sarcoma180 implanted ICR mice, life prolongation effects of Compound Ⅰ and Ⅱ were showed as 143% and 134% at the dose of 10㎎/㎏, respectively. Besides, at the tested group mixed Compound Ⅰ and Ⅱ each 1㎎/㎏ was showed rather high life prolongation effect as 158%.
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KEYWORD
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sesquiterpene lactones, antitumor agents, life prolongation effect
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